Published Papers on Xe MRI

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Selected Papers from 2025

• Mapping Regional Changes in Multiple-Timepoint Hyperpolarized Gas Ventilation Images and Validation by Radiologist Score. Shammi UA, Altes T, Thornburgh C, Mugler JP 3rd, Meyer CH, Qing K, de Lange XEE, Mata J, Thomen R. Int J Biomed Imaging. 2025 Dec 5;2025:1959442. doi: 10.1155/ijbi/1959442. eCollection 2025. PMID: 4147644

• Structural and Functional Lung Assessment in Neonates With Moderate to Severe Bronchopulmonary Dysplasia Using 3D Ultra-Short Echo Time MRI. Munidasa S, Higano NS, Willmering M, Matheson AM, Fleck RJ, Kingma PS, Hysinger EB, Woods JC. J Magn Reson Imaging. 2025 Dec 12. doi: 10.1002/jmri.70203. Online ahead of print. PMID: 41387201

• Ethyl Pyruvate Promotes Wound Healing in Elastase-Induced Lung Injury in Mice as Assessed by Hyperpolarized 129Xe Magnetic Resonance Imaging. Kimura A, Shimokawa A, Stewart NJ, Hosoi R, Imai H, Fujiwara H. Mol Imaging Biol. 2025 Dec 10. doi: 10.1007/s11307-025-02073-6. Online ahead of print. PMID: 41372714

• Heterogeneity of short-term elexacaftor-tezacaftor-ivacaftor response in cystic fibrosis using 129Xe MRI. Eddy RL, Diamond VM, Chrenek J, Bhatnagar G, Sag D, Ghadymimahani R, Aulakh A, Ha BX, Quon BS, Rayment JH. Thorax. 2025 Dec 9:thorax-2025-223687. doi: 10.1136/thorax-2025-223687. Online ahead of print. PMID: 41365630

• Long COVID: lung pathophysiology and its relationship with cognitive dysfunction. Staab KR, McIntosh MJ, Puliyakote ASK, Hahn AD, AlArab N, Percy JL, Lanning T, Theeler J, Linkenmeyer C, Wharff CJ, Bruening E, Sieren JC, Hoffman EA, Comellas AP, Hoth KF, Fain SB. Sci Rep. 2025 Nov 24;15(1):42595. doi: 10.1038/s41598-025-26568-y. PMID: 41286257

• Deep Learning Reconstruction for 129Xe Diffusion-Weighted MRI Enables Use of Natural Abundant Xenon and Improved Image Acceleration. Sundaresan R, Collier GJ, Stewart NJ, Chatterjee S, Venkatesan R, Wolber J, Wild JM. Magn Reson Med. 2025 Nov 20. doi: 10.1002/mrm.70194. Online ahead of print. PMID: 41266932

• Comparing Mean-anchored Generalized Linear Binning with Established Methods to Quantify Xenon-129 Ventilation Defect Percentage. Hussain R, Bdaiwi AS, Plummer JW, Masokano BI, Willmering MM, Walkup LL, Cleveland ZI. Acad Radiol. 2025 Nov 14:S1076-6332(25)01030-X. doi: 10.1016/j.acra.2025.10.044. Online ahead of print. PMID: 41241593

• Structural and Functional Pulmonary MRI to Predict Pulmonary Exacerbations in Cystic Fibrosis. Matheson AM, Bdaiwi AS, Willmering MM, DiFrancesco MW, Cleveland ZI, Santyr GE, Ratjen F, Kramer EL, Szczesniak RD, Woods JC. Chest. 2025 Nov 13:S0012-3692(25)05689-2. doi: 10.1016/j.chest.2025.10.041. Online ahead of print. PMID: 41241146

• Clinical, physiologic, imaging, and molecular responses to cannabis smoking: the Canadian Users of Cannabis Smoke (CANUCK) Study. Leung C, Gilchrist CL, Wang CJ, Liggins JA, Li X, Yang J, Cheung CY, Gerayeli FV, Singhera GK, Hsu WJ, Lidher LS, Moo K, Leyson E, Dhillon SS, Shaipanich T, Leipsic JA, Guenette JA, Rayment JH, Kirby M, Gershon AS, Sadatsafavi M, Tan WC, Parraga G, Carlsten C, Eddy RL, Sin DD, Leung JM. Eur Respir J. 2025 Nov 6:2501659. doi: 10.1183/13993003.01659-2025. Online ahead of print. PMID: 41198398

• Keeping it simple: lung imaging of alveolar simplification in preterm-birth children. Matheson AM, Parraga G. ERJ Open Res. 2025 Oct 27;11(5):00528-2025. doi: 10.1183/23120541.00528-2025. eCollection 2025 Sep. PMID: 41158502

• Comparative Analysis of Foundational, Advanced, and Traditional Deep Learning Models for Hyperpolarized Gas MRI Lung Segmentation: Robust Performance in Data-Constrained Scenarios. Babaeipour R, Fox MS, Parraga G, Ouriadov A. Bioengineering (Basel). 2025 Sep 30;12(10):1062. doi: 10.3390/bioengineering12101062. PMID: 41155061

• Breathing Lessons: How Xenon MRI Is Resolving the Overlap Between Asthma and COPD. Shim YM, Woods J, Mugler JP. Am J Respir Crit Care Med. 2025 Oct 24. doi: 10.1164/rccm.202509-2258ED. Online ahead of print. PMID: 41135035

• Visualizing Improvements in Airway Dysfunction After Inhaled Therapy in Patients With Uncontrolled Asthma: A Narrative Review. Tcherner S, Mozaffaripour A, Yamashita C, Parraga G. Adv Ther. 2025 Dec;42(12):5950-5959. doi: 10.1007/s12325-025-03392-4. Epub 2025 Oct 24. PMID: 41134514

• Serial MRI Measures Short-term Parenchymal Changes in Neonatal Bronchopulmonary Dysplasia. Munidasa S, Higano NS, Willmering MM, Bdaiwi AS, Cordon XH, Elias DB, Fleck RJ, Kingma PS, Hysinger EB, Woods JC. Chest. 2025 Oct 14:S0012-3692(25)05527-8. doi: 10.1016/j.chest.2025.10.010. Online ahead of print. PMID: 41101640

• Airway mucus and 129Xe MRI ventilation after single inhaler triple therapy in asthma. Mozaffaripour A, Tcherner S, Durom E, Kooner HK, McIntosh MJ, Sherwood M, Paul N, Serajeddini H, Bhalla A, Yamashita C, Parraga G. ERJ Open Res. 2025 Oct 13;11(5):01333-2024. doi: 10.1183/23120541.01333-2024. eCollection 2025 Sep. PMID: 41089567

• Evaluating Stack-of-Stars and FLORET 3D Ultrashort Echo Time MRI to Assess Structural Pathology in Cystic Fibrosis Lung Disease. Bdaiwi AS, Willmering MM, Plummer JW, Hussain R, Walkup LL, Woods JC, Cleveland ZI. Acad Radiol. 2025 Oct 13:S1076-6332(25)00915-8. doi: 10.1016/j.acra.2025.09.036. Online ahead of print. PMID: 41087234

• Phenotyping Asthma and/or COPD Using 129Xe MRI and Comprehensive Physiologic Testing. Marshall H, Smith LJ, Biancardi AM, Collier GJ, Chan HF, Hughes PJ, Brook ML, Astley JR, Munro R, Rajaram S, Swift AJ, Capener D, Bray J, Ball JE, Rodgers O, Jakymelen DJ, Tahir BA, Rao M, Norquay G, Weatherley ND, Armstrong L, Hardaker L, Papi A, Reddel HK, Müllerová H, Hughes R, Wild JM. Am J Respir Crit Care Med. 2025 Oct 10. doi: 10.1164/rccm.202501-0288OC. Online ahead of print. PMID: 41072430

• Optimizing Xenon 129 Ventilation MRI in Cystic Fibrosis with Spiral Imaging and Flip-Angle Correction. Hussain R, Plummer JW, Bdaiwi AS, Willmering MM, Kramer EL, Walkup LL, Cleveland ZI. Radiol Cardiothorac Imaging. 2025 Oct;7(5):e240574. doi: 10.1148/ryct.240574. PMID: 41037010

• Xe MRI Detects Ongoing Ventilation Improvements in People with Cystic Fibrosis Receiving Highly Effective Modulator Therapy. Hussain R, Masokano BI, Plummer JW, Bdaiwi AS, Willmering MM, Kramer EL, Walkup LL, Cleveland ZI. Ann Am Thorac Soc. 2025 Sep 25:10.1513/AnnalsATS.202505-497RL. doi: 10.1513/AnnalsATS.202505-497RL. Online ahead of print. PMID: 40996328

• Comparison of phase-resolved functional lung (PREFUL) and hyperpolarized 129Xe MRI for longitudinal monitoring of lung function in pediatric cystic fibrosis following elexacaftor/tezacaftor/ivacaftor. Munidasa S, Alam F, Zanette B, Li D, Wee W, Braganza S, Woods J, Ratjen F, Santyr G. Pediatr Radiol. 2025 Dec;55(13):2800-2812. doi: 10.1007/s00247-025-06390-4. Epub 2025 Sep 12. PMID: 40938435

• Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI. Khan AS, Laustsen C. J Magn Reson Imaging. 2025 Sep 1. doi: 10.1002/jmri.70084. Online ahead of print. PMID: 40888668

• Robust Segmentation of Lung Proton and Hyperpolarized Gas MRI with Vision Transformers and CNNs: A Comparative Analysis of Performance Under Artificial Noise. Babaeipour R, Fox MS, Parraga G, Ouriadov A. Bioengineering (Basel). 2025 Jul 28;12(8):808. doi: 10.3390/bioengineering12080808. PMID: 40868321

• Optimizing reliability of RBC signal oscillation measures from hyperpolarized 129Xe MRI. Mali I, Frizzell B, Haworth S, Niedbalski PJ. PLoS One. 2025 Aug 26;20(8):e0331113. doi: 10.1371/journal.pone.0331113. eCollection 2025. PMID: 40857293

• Ventilation defect burden predicts lung cancer resection outcomes. Radadia N, Priel E, Friedlander Y, Konyer NB, Huang C, Jamal M, Farncombe T, Marriott C, Finley C, Agzarian J, Noseworthy MD, Nair P, Shargall Y, Svenningsen S. ERJ Open Res. 2025 Aug 18;11(4):01317-2024. doi: 10.1183/23120541.01317-2024. eCollection 2025 Jul. PMID: 40831991

• Comparative evaluation of supervised and unsupervised deep learning strategies for denoising hyperpolarized 129Xe lung MRI. Bdaiwi AS, Willmering MM, Hussain R, Hysinger E, Woods JC, Walkup LL, Cleveland ZI. Magn Reson Med. 2026 Jan;95(1):138-156. doi: 10.1002/mrm.70033. Epub 2025 Aug 14. PMID: 40810302

• Multicenter Study of Hyperpolarized Xenon Magnetic Resonance Imaging in Children with Cystic Fibrosis Following Initiation of Cystic Fibrosis Transmembrane Regulator Modulator Therapy (HyPOINT). Ratjen FA, Stanojevic S, Munidasa S, Roach D, Mata J, Froh DK, Zanette B, Santyr G, Fain SB, Rock MJ, Walkup LL, Woods JC. Ann Am Thorac Soc. 2025 Dec;22(12):1891-1899. doi: 10.1513/AnnalsATS.202501-028OC. PMID: 40795189

• Hyperpolarized 129Xe MRI and Spectroscopy: Quantitative Measurements, Results, and Emerging Opportunities. Schmidt A, Liggins JA, Bhutta H, Dell SD, Leung JM, Sin DD, Leipsic JA, Rayment JH, Eddy RL. Radiol Cardiothorac Imaging. 2025 Aug;7(4):e240562. doi: 10.1148/ryct.240562. PMID: 40772846

• Plug-and-Play Self-Supervised Denoising for Pulmonary Perfusion MRI. Sun C, Wang Y, Thornburgh C, Lin AL, Qing K, Mugler JP 3rd, Altes TA. Bioengineering (Basel). 2025 Jul 1;12(7):724. doi: 10.3390/bioengineering12070724. PMID: 40722417

• Longitudinal Monitoring of Lumacaftor/Ivacaftor Response in Young Children with Cystic Fibrosis Lung Disease Using 129Xe MRI. Bdaiwi AS, Roach DJ, West ME, Willmering MM, Daou AW, Hossain MM, Kramer EL, Amin R, Walkup LL, Cleveland ZI, Woods JC. Acad Radiol. 2025 Oct;32(10):6238-6249. doi: 10.1016/j.acra.2025.06.042. Epub 2025 Jul 10. PMID: 40645890

• Disease Classification of Pulmonary Xenon Ventilation MRI Using Artificial Intelligence. Matheson AM, Bdaiwi AS, Willmering MM, Hysinger EB, McCormack FX, Walkup LL, Cleveland ZI, Woods JC. Acad Radiol. 2025 Oct;32(10):6330-6342. doi: 10.1016/j.acra.2025.06.024. Epub 2025 Jul 5. PMID: 40617705

• The emerging role of hyperpolarized 129Xe MRI in pulmonary hypertension. Alenezi F, Costelle A, Lee S, Driehuys B, Rajagopal S. Expert Rev Respir Med. 2025 Dec;19(12):1161-1165. doi: 10.1080/17476348.2025.2529543. Epub 2025 Jul 10. PMID: 40600715

• Respiratory burden in post-acute COVID-19 sequelae: a longitudinal study of airway and systemic inflammation and clinical outcomes. Chiu MN, Chowdhury A, Zhang K, Somalwar S, Jamil R, Thakar A, Sidhom K, Sedhom N, Thanavala N, Mukherjee M, Kjarsgaard M, Venegas CG, Radadia N, Tan NS, Patel Z, Ahammed N, Isshiki T, Nolasco S, Chagla Z, Kolb M, Duong M, Gershon AS, Nair P, Satia I, Tselios K, Ho T, Balakrishnan N, Svenningsen S, Mukherjee M. ERJ Open Res. 2025 Jun 23;11(3):01331-2024. doi: 10.1183/23120541.01331-2024. eCollection 2025 May. PMID: 4055179

• Establishing standardized healthy reference distributions and values for multisite 129Xe gas exchange MRI/MR spectroscopy at 3 T across major scanner platforms. Leewiwatwong S, Bechtel A, Mummy D, Zhang S, Lu J, Costelle A, Cleveland ZI, Willmering M, Parra-Robles J, Fain S, Hahn AD, Tighe RM, Driehuys B. Magn Reson Med. 2025 Oct;94(4):1684-1699. doi: 10.1002/mrm.30586. Epub 2025 Jun 2. PMID: 40457620

• Finite element modeling of Rb-129Xe spin-exchange optical pumping and optimized Rb source distribution. Ball JE, Wild JM, Norquay G. J Magn Reson. 2025 Aug;377:107889. doi: 10.1016/j.jmr.2025.107889. Epub 2025 May 30. PMID: 40449139

• 129Xe-MRI ventilation and acinar abnormalities highlight the significance of spirometric dysanapsis: findings from the NOVELTY ADPro UK substudy. Smith LJ, Marshall H, Jakymelen D, Biancardi A, Collier GJ, Chan HF, Hughes PJC, Brook ML, Astley JR, Munro R, Rajaram S, Swift AJ, Capener D, Bray J, Ball JE, Rodgers O, Tahir BA, Rao M, Norquay G, Weatherley ND, Armstrong L, Hardaker L, Papi A, Hughes R, Wild JM. Thorax. 2025 Nov 14;80(12):909-917. doi: 10.1136/thorax-2024-222347. PMID: 40425296

• MR Spectroscopic Imaging of Hyperpolarized 129-Xenon in the Dissolved-Phase to Determine Regional Chemical Shifts of Hyperoxia in Healthy Porcine Lungs. Vaeggemose M, Kristensen MH, Redda M, Hansen ESS, Rodgers O, Collier GJ, Norquay G, Wild JM, Laustsen C, Schulte RF. NMR Biomed. 2025 Jun;38(6):e70063. doi: 10.1002/nbm.70063. PMID: 40384034

• Quantification of 129Xe MRI Ventilation-defect-percent Using Binary-threshold, Gaussian Linear-Binning and K-means Methods: Differences in Asthma and COPD. Durom E, Yang C, Mozaffaripour A, Matheson AM, Eddy RL, Svenningsen S, Parraga G. Acad Radiol. 2025 May 5:S1076-6332(25)00381-2. doi: 10.1016/j.acra.2025.04.030. Epub ahead of print. PMID: 40328537.

• Design and Implementation of a Multi-Center Trial of 129Xe Gas Exchange MRI and MRS to Evaluate Longitudinal Progression of COPD. Driehuys B, Zhang S, Bechtel A, Hahn AD, Collier G, Niedbalski PJ, Huang YC, Cleveland ZI, Willmering MM, Mugler JP 3rd, Mata J, Shim YM, Castro M, Svenningsen S, Friedlander Y, Ho T, Fain S, Hoffman EA, Wild JM, Thomen RP, Altes T, Shammi UA, Harris W, Zou Y, Fernandez Coimbra A, Belloni P, Bell LC, Mummy D. J Magn Reson Imaging. 2025 Apr 23. doi: 10.1002/jmri.29769. Epub ahead of print. PMID: 40266001.

• Functional Pulmonary Imaging. Kern AL, Klimeš F, Voskrebenzev A, Shin HO, Vogel-Claussen J. J Magn Reson Imaging. 2025 Apr 11. doi: 10.1002/jmri.29778. Epub ahead of print. PMID: 40213976.

• Application of the defect distribution index to functional lung MRI of pediatric cystic fibrosis lung disease and controls. Kieninger E, Munidasa S, Curdy M, Streibel C, Zanette B, Woods J, Latzin P, Ratjen F, Santyr G. J Cyst Fibros. 2025 Mar 10:S1569-1993(25)00065-7. doi: 10.1016/j.jcf.2025.02.015. Epub ahead of print. PMID: 40069051.

• A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging. Diamond VM, Bell LC, Bone JN, Driehuys B, Menchaca M, Santyr G, Svenningsen S, Thomen RP, Marshall H, Smith LJ, Collier GJ, Wild JM, Woods JC, Fain SB, Eddy RL, Rayment JH. J Magn Reson Imaging. 2025 Feb 26. doi: 10.1002/jmri.29746. Epub ahead of print. PMID: 40012090.

• Hyperpolarized Xenon-129 MRI: Narrative Review of Clinical Studies, Testing, and Implementation of Advanced Pulmonary In Vivo Imaging and Its Diagnostic Applications. MacLeod JL, Khan HM, Franklin A, Myc L, Shim YM. Diagnostics (Basel). 2025 Feb 16;15(4):474. doi: 10.3390/diagnostics15040474. PMID: 40002625; PMCID: PMC11854573.

• A framework for modelling whole-lung and regional transfer factor of the lung for carbon monoxide using hyperpolarised xenon-129 lung magnetic resonance imaging. Pilgrim-Morris JH, Smith LJ, Marshall H, Tahir BA, Collier GJ, Stewart NJ, Wild JM. ERJ Open Res. 2025 Feb 10;11(1):00442-2024. doi: 10.1183/23120541.00442-2024. PMID: 39931664; PMCID: PMC11808933.

• Xenon-129 magnetic resonance imaging and spectroscopy detects response to therapy in pulmonary hypertension. Alenezi F, Costelle A, Sharma P, Barrett M, Bier EA, Driehuys B, Rajagopal S. Xenon-129 magnetic resonance imaging and spectroscopy detects response to therapy in pulmonary hypertension. Eur Respir J. 2025 Feb 27;65(2):2401651. doi: 10.1183/13993003.01651-2024. PMID: 39884765; PMCID: PMC11890203.

• Combining hyperpolarized 129Xe MR imaging and spectroscopy to noninvasively estimate pulmonary vascular resistance. Costelle A, Lu J, Leewiwatwong S, Westerhof B, Mummy D, Rajagopal S, Driehuys B. J Appl Physiol (1985). 2025 Mar 1;138(3):623-633. doi: 10.1152/japplphysiol.00440.2024. Epub 2025 Jan 28. PMID: 39873409.

• Quantifying spatial and dynamic lung abnormalities with 3D PREFUL FLORET UTE imaging: A feasibility study. Klimeš F, Plummer JW, Willmering MM, Matheson AM, Bdaiwi AS, Gutberlet M, Voskrebenzev A, Wernz MM, Wacker F, Woods J, Cleveland ZI, Walkup LL, Vogel-Claussen J. Magn Reson Med. 2025 May;93(5):1984-1998. doi: 10.1002/mrm.30416. Epub 2025 Jan 17. PMID: 39825520; PMCID: PMC11893037.

• A thermally polarized, dissolved-phase 129Xe phantom for quality-control and multisite comparisons of gas-exchange imaging. Willmering MM, Albert BJ, Plummer JW, Greer J, Walkup LL, Lindquist DM, Cleveland ZI. J Magn Reson. 2025 Feb;371:107829. doi: 10.1016/j.jmr.2025.107829. Epub 2025 Jan 13. PMID: 39809025; PMCID: PMC11807756.

Selected Papers from 2024

• Improving Xenon-129 lung ventilation image SNR with deep-learning based image reconstruction. Stewart NJ, de Arcos J, Biancardi AM, Collier GJ, Smith LJ, Norquay G, Marshall H, Brau ACS, Lebel RM, Wild JM.Magn Reson Med. 2024 Dec;92(6):2546-2559. doi: 10.1002/mrm.30250. Epub 2024 Aug 18.PMID: 39155454

• A decay-modeled compressed sensing reconstruction approach for non-Cartesian hyperpolarized 129Xe MRI. Plummer JW, Hussain R, Bdaiwi AS, Soderlund SA, Hoyos X, Lanier JM, Garrison WJ, Parra-Robles J, Willmering MM, Niedbalski PJ, Cleveland ZI, Walkup LL.Magn Reson Med. 2024 Oct;92(4):1363-1375. doi: 10.1002/mrm.30188. Epub 2024 Jun 11.PMID: 38860514

• Age, sex, and lung volume dependence of dissolved xenon-129 MRI gas exchange metrics. Collier GJ, Smith LJ, Saunders LC, Swift AJ, Marshall H, Stewart NJ, Norquay G, Hughes PJC, Thomspson AAR, Wild JM.Magn Reson Med. 2024 Oct;92(4):1471-1483. doi: 10.1002/mrm.30133. Epub 2024 May 10.PMID: 38726472

• Compressed sensing reconstruction for high-SNR, rapid dissolved 129Xe gas exchange MRI. Pilgrim-Morris JH, Collier GJ, Munro RS, Norquay G, Stewart NJ, Wild JM.Magn Reson Med. 2024 Sep 25. doi: 10.1002/mrm.30312. Online ahead of print.PMID: 39323101

• Comparison of 3D UTE free-breathing lung MRI with hyperpolarized 129Xe MRI in pediatric cystic fibrosis. Munidasa S, Zanette B, Dumas MP, Wee W, Braganza S, Li D, Ratjen F, Santyr G. Magn Reson Med. 2024 Sep 16. doi: 10.1002/mrm.30299. Online ahead of print. PMID: 39285622

• Invisible Insights: Probing Lung Function with 129Xe MRI. Hall CS. Acad Radiol. 2024 Sep 11:S1076-6332(24)00649-4. doi: 10.1016/j.acra.2024.08.062. Online ahead of print. PMID: 39266445No abstract available.

• Same-Day Repeatability and 28-Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi-Site Trial. Walkup LL, Roach DJ, Plummer JW, Willmering MM, Zanette B, Santyr G, Fain SB, Rock MJ, Mata J, Froh D, Stanojevic S, Cleveland ZI, Ratjen F, Woods JC. J Magn Reson Imaging. 2024 Sep 11. doi: 10.1002/jmri.29605. Online ahead of print. PMID: 39257323

• Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarized 129Xe diffusion MRI. Bdaiwi AS, Svoboda AM, Murdock KE, Hendricks A, Hossain MM, Kramer EL, Brewington JJ, Willmering MM, Woods JC, Walkup LL, Cleveland ZI. J Cyst Fibros. 2024 Sep;23(5):926-935. doi: 10.1016/j.jcf.2024.07.002. Epub 2024 Jul 14. PMID: 38997823

• 129Xe MRI Ventilation Textures and Longitudinal Quality-of-Life Improvements in Long-COVID. Kooner HK, Sharma M, McIntosh MJ, Dhaliwal I, Nicholson JM, Kirby M, Svenningsen S, Parraga G. Acad Radiol. 2024 Sep;31(9):3825-3836. doi: 10.1016/j.acra.2024.03.014. Epub 2024 Apr 18. PMID: 38637239

• Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized 129Xe Gas Exchange Magnetic Resonance Imaging. Rankine LJ, Lu J, Wang Z, Kelsey CR, Marks LB, Das SK, Driehuys B. Int J Radiat Oncol Biol Phys. 2024 Sep 1;120(1):216-228. doi: 10.1016/j.ijrobp.2024.02.049. Epub 2024 Mar 5. PMID: 38452858

• Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized 129Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers. Klimeš F, Kern AL, Voskrebenzev A, Gutberlet M, Grimm R, Müller RA, Behrendt L, Kaireit TF, Glandorf J, Alsady TM, Wacker F, Hohlfeld JM, Vogel-Claussen J. Eur Radiol. 2024 Jul 26. doi: 10.1007/s00330-024-10893-3. Online ahead of print. PMID: 39060494

• Improved Diffusion-Weighted Hyperpolarized 129Xe Lung MRI with Patch-Based Higher-Order, Singular Value Decomposition Denoising. Soderlund SA, Bdaiwi AS, Plummer JW, Woods JC, Walkup LL, Cleveland ZI. Acad Radiol. 2024 Jul 3:S1076-6332(24)00388-X. doi: 10.1016/j.acra.2024.06.029. Online ahead of print. PMID: 38960843

• Sampling pattern discrepancy in the application of compressed sensing hyperpolarized xenon-129 lung MRI. Tavakkoli M, Svenningsen S, Friedlander Y, Konyer NB, Nair P, Noseworthy MD. NMR Biomed. 2024 Jun;37(6):e5121. doi: 10.1002/nbm.5121. Epub 2024 Feb 29. PMID: 38423986

• Using the full power of multiple hyperpolarized 129Xe contrasts to interrogate aging, smoking, and COPD. Niedbalski PJ, Castro M. Eur Radiol. 2024 May 31. doi: 10.1007/s00330-024-10822-4. Online ahead of print. PMID: 38819516No abstract available.

• Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function. Eddy RL, Xu GH, Leipsic JA, Leung JM, Sin DD, Hall CS, Tam RC. J Vis Exp. 2024 Apr 12;(206). doi: 10.3791/66257. PMID: 38682932

• Functional gas exchange measures on 129Xe MRI and spectroscopy are associated with age, sex, and BMI in healthy subjects. Mummy D, Zhang S, Bechtel A, Lu J, Mammarappallil J, Leewiwatwong S, Costelle A, Swaminathan A, Driehuys B. Front Med (Lausanne). 2024 Apr 8;11:1342499. doi: 10.3389/fmed.2024.1342499. eCollection 2024. PMID: 38651062Free PMC article.

• Pulmonary MRI with hyperpolarized xenon-129 demonstrates novel alterations in gas transfer across the air-blood barrier in asthma. Qing K, Altes TA, Mugler JP 3rd, Tustison NJ, Mata, Ruppert K, Komlosi P, Feng X, Nie K, Zhao L, Wang Z, Hersman FW, Ruset IC, Liu B, Shim YM, Teague WG. Med Phys. 2024 Apr;51(4):2413-2423. doi: 10.1002/mp.17009. Epub 2024 Mar 3. PMID: 38431967

• Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarized 129 Xe gas exchange MRI: Digital phantoms and clinical evaluation in CTEPH. Lu J, Alenezi F, Bier E, Leewiwatwong S, Mummy D, Kabir S, Rajagopal S, Robertson S, Niedbalski PJ, Driehuys B. Magn Reson Med. 2024 Apr;91(4):1541-1555. doi: 10.1002/mrm.29965. Epub 2023 Dec 12. PMID: 38084439

• Hyperpolarized 129Xe MRI, 99mTc scintigraphy, and SPECT in lung ventilation imaging: a quantitative comparison. Peiffer JD, Altes T, Ruset IC, Hersman FW, Mugler JP 3rd, Meyer CH, Mata J, Qing K, Thomen R. Acad Radiol. 2024 Apr;31(4):1666-1675. doi: 10.1016/j.acra.2023.10.038. Epub 2023 Nov 17. PMID: 37977888

• Review of Hyperpolarized Pulmonary Functional 129 Xe MR for Long-COVID. Wild JM, Gleeson FV, Svenningsen S, Grist JT, Saunders LC, Collier GJ, Sharma M, Tcherner S, Mozaffaripour A, Matheson AM, Parraga G. J Magn Reson Imaging. 2024 Apr;59(4):1120-1134. doi: 10.1002/jmri.28940. Epub 2023 Aug 7. PMID: 37548112Review.

• Cluster Analysis to Identify Long COVID Phenotypes Using 129Xe Magnetic Resonance Imaging: A Multi-centre Evaluation. Eddy RL, Mummy D, Zhang S, Dai H, Bechtel A, Schmidt A, Frizzell B, Gerayeli FV, Leipsic JA, Leung JM, Driehuys B, Que LG, Castro M, Sin DD, Niedbalski PJ. Eur Respir J. 2024 Feb 8;63(3):2302301. doi: 10.1183/13993003.02301-2023. Online ahead of print. PMID: 38331459Free PMC article.

• 129Xe MRI and Oscillometry of Irritant-Induced Asthma After Bronchial Thermoplasty. McIntosh MJ, Hofmann JJ, Kooner HK, Eddy RL, Parraga G, Mackenzie CA. Chest. 2024 Feb;165(2):e27-e31. doi: 10.1016/j.chest.2023.09.010. PMID: 38336440

• Troubleshooting and Quality Assurance in Hyperpolarized Xenon Magnetic Resonance Imaging: Tools for High-Quality Image Acquisition. Shammi UA, Garcίa Delgado GM, Thomen R. J Vis Exp. 2024 Jan 5;(203). doi: 10.3791/65972. PMID: 38251797

Selected Papers from 2023

• Childhood to adulthood: Accounting for age dependence in healthy-reference distributions in 129 Xe gas-exchange MRI. Plummer JW, Willmering MM, Cleveland ZI, Towe C, Woods JC, Walkup LL. Magn Reson Med. 2023 Mar;89(3):1117-1133

• Intra- and Inter-visit Repeatability of 129 Xenon Multiple-Breath Washout MRI in Children With Stable Cystic Fibrosis Lung Disease. Alam FS, Zanette B, Munidasa S, Braganza S, Li D, Woods JC, Ratjen F, Santyr G. J Magn Reson Imaging. 2023 Sep;58(3):936-948

• Hyperpolarized 129Xe MRI, 99mTc scintigraphy, and SPECT in lung ventilation imaging: a quantitative comparison. Peiffer JD, Altes T, Ruset IC, Hersman FW, Mugler JP 3rd, Meyer CH, Mata J, Qing K, Thomen R. Acad Radiol. 2023 Nov 15:S1076-6332(23)00591-3

• Undersampled Diffusion-Weighted 129Xe MRI Morphometry of Airspace Enlargement: Feasibility in Chronic Obstructive Pulmonary Disease. Perron S, McCormack DG, Parraga G, Ouriadov A. Diagnostics (Basel). 2023 Apr 19;13(8):1477

• Functional xenon-129 magnetic resonance imaging response to antifibrotic treatment in idiopathic pulmonary fibrosis. Hahn AD, Carey KJ, Barton GP, Torres LA, Kammerman J, Cadman RV, Lee KE, Schiebler ML, Sandbo N, Fain SB. ERJ Open Res. 2023 Jun 26;9(3):00080-2023

• Lung Volume Dependence and Repeatability of Hyperpolarized 129Xe MRI Gas Uptake Metrics in Healthy Volunteers and Participants with COPD. Garrison WJ, Qing K, He M, Zhao L, Tustison NJ, Patrie JT, Mata JF, Shim YM, Ropp AM, Altes TA, Mugler JP 3rd, Miller GW. Radiol Cardiothorac Imaging. 2023 Jun 22;5(3):e220096

• 129 Xe and Free-Breathing 1 H Ventilation MRI in Patients With Cystic Fibrosis: A Dual-Center Study. Marshall H, Voskrebenzev A, Smith LJ, Biancardi AM, Kern AL, Collier GJ, Wielopolski PA, Ciet P, Tiddens HAWM, Vogel-Claussen J, Wild JM. J Magn Reson Imaging. 2023 Jun;57(6):1908-1921

• Postacute COVID-19 Syndrome: 129Xe MRI Ventilation Defects and Respiratory Outcomes 1 Year Later. Kooner HK, McIntosh MJ, Matheson AM, Abdelrazek M, Albert MS, Dhaliwal I, Kirby M, Ouriadov A, Santyr GE, Venegas C, Radadia N, Svenningsen S, Nicholson JM, Parraga G. Radiology. 2023 Apr;307(2):e222557

• Inter- and intravisit repeatability of free-breathing MRI in pediatric cystic fibrosis lung disease. Munidasa S, Zanette B, Couch M, Grimm R, Seethamraju R, Dumas MP, Wee W, Au J, Braganza S, Li D, Woods J, Ratjen F, Santyr G. Magn Reson Med. 2023 May;89(5):2048-2061

• Initial feasibility and challenges of hyperpolarized 129 Xe MRI in neonates with bronchopulmonary dysplasia. Stewart NJ, Higano NS, Mukthapuram S, Willmering MM, Loew W, West M, Arnsperger A, Pratt R, Rao MR, Schulte RF, Wild JM, Woods JC. Magn Reson Med. 2023 Dec;90(6):2420-2431

• Establishing a hemoglobin adjustment for 129 Xe gas exchange MRI and MRS. Bechtel A, Lu J, Mummy D, Bier E, Leewiwatwong S, Mugler J 3rd, Kabir S, Church A, Driehuys B. Magn Reson Med. 2023 Oct;90(4):1555-1568

• Editorial for "A Dual-Channel Deep Learning Approach for Lung Cavity Estimation From Hyperpolarized Gas and Proton MRI". Munidasa S, Santyr G. J Magn Reson Imaging. 2023 Jun;57(6):1891-1892

• More Data about 129Xe MRI Ventilation Defects in Long COVID-19. Kooner HK, McIntosh MJ, Matheson AM, Svenningsen S, Parraga G. Radiology. 2023 May;307(4):e230479

• Hyperpolarized Xenon-129: A New Tool to Assess Pulmonary Physiology in Patients with Pulmonary Fibrosis. Qing K, Altes TA, Mugler JP 3rd, Mata JF, Tustison NJ, Ruppert K, Bueno J, Flors L, Shim YM, Zhao L, Cassani J, Teague WG, Kim JS, Wang Z, Ruset IC, Hersman FW, Mehrad B. Biomedicines. 2023 May 25;11(6):1533

• A single-breath-hold protocol for hyperpolarized 129 Xe ventilation and gas exchange imaging. Niedbalski PJ, Willmering MM, Thomen RP, Mugler JP 3rd, Choi J, Hall C, Castro M. NMR Biomed. 2023 Aug;36(8):e4923.

• Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity. Wang Z, Rankine L, Bier EA, Mummy D, Lu J, Church A, Tighe RM, Swaminathan A, Huang YT, Que LG, Mammarappallil JG, Rajagopal S, Driehuys B. J Appl Physiol (1985). 2021 May 1;130(5):1398-1409. doi: 10.1152/japplphysiol.00702.2020.

Selected Papers from 2022

• Comparison of Hyperpolarized 3He and 129Xe MR Imaging in Cystic Fibrosis Patients. Shammi UA, D'Alessandro MF, Altes T, Hersman FW, Ruset IC, Mugler J 3rd, Meyer C, Mata J, Qing K, Thomen R. Acad Radiol. 2022 Feb;29 Suppl 2:S82-S90. doi: 10.1016/j.acra.2021.01.007.

• Hyperpolarized 129Xenon MRI Ventilation Defect Quantification via Thresholding and Linear Binning in Multiple Pulmonary Diseases. Roach DJ, Willmering MM, Plummer JW, Walkup LL, Zhang Y, Hossain MM, Cleveland ZI, Woods JC. Acad Radiol. 2022 Feb;29 Suppl 2(Suppl 2):S145-S155.

Selected Papers from 2021

• Reproducibility of Hyperpolarized 129Xe MRI Ventilation Defect Percent in Severe Asthma to Evaluate Clinical Trial Feasibility. Svenningsen S, McIntosh M, Ouriadov A, Matheson AM, Konyer NB, Eddy RL, McCormack DG, Noseworthy MD, Nair P, Parraga G. Acad Radiol. 2021 Jun;28(6):817-826.

• Hyperpolarized 129Xe MRI Abnormalities in Dyspneic Patients 3 Months after COVID-19 Pneumonia: Preliminary Results. Grist JT, Chen M, Collier GJ, Raman B, Abueid G, McIntyre A, Matthews V, Fraser E, Ho LP, Wild JM, Gleeson F. Radiology. 2021 Oct;301(1):E353-E360.

• Novel imaging techniques for cystic fibrosis lung disease. Goralski JL, Stewart NJ, Woods JC. Pediatr Pulmonol. 2021 Feb;56 Suppl 1(Suppl 1):S40-S54.

• Removal of off-resonance xenon gas artifacts in pulmonary gas-transfer MRI. Willmering MM, Cleveland ZI, Walkup LL, Woods JC. Magn Reson Med. 2021 Aug;86(2):907-915.

• Sensitive structural and functional measurements and 1-year pulmonary outcomes in pediatric cystic fibrosis. Willmering MM, Roach DJ, Kramer EL, Walkup LL, Cleveland ZI, Woods JC. J Cyst Fibros. 2021 May;20(3):533-539. doi: 10.1016/j.jcf.2020.11.019.

• Regional Structure-Function in Cystic Fibrosis Lung Disease Using Hyperpolarized 129Xe and Ultrashort Echo Magnetic Resonance Imaging. Thomen RP, Walkup LL, Roach DJ, Higano N, Schapiro A, Brody A, Clancy JP, Cleveland ZI, Woods JC. Am J Respir Crit Care Med. 2020 Jul 15;202(2):290-292.

• 129Xe MRI as a measure of clinical disease severity for pediatric asthma. Lin NY, Roach DJ, Willmering MM, Walkup LL, Hossain MM, Desirazu P, Cleveland ZI, Guilbert TW, Woods JC.J Allergy Clin Immunol. 2021 Jun;147(6):2146-2153.e1. doi: 10.1016/j.jaci.2020.11.010.

Selected Papers from 2020 & Prior

• Current state of the art MRI for the longitudinal assessment of cystic fibrosis. Woods JC, Wild JM, Wielpütz MO, Clancy JP, Hatabu H, Kauczor HU, van Beek EJR, Altes TA. J Magn Reson Imaging. 2019 Dec 17. doi: 10.1002/jmri.27030. [Epub ahead of print] Review.Hossain MM, Desirazu P, Cleveland ZI, Guilbert TW, Woods JC. J Allergy Clin Immunol. 2021 Jun;147(6):2146-2153.e1.

• Cyst Ventilation Heterogeneity and Alveolar-Airspace Dilation as Early Disease Markers in Lymphangioleiomyomatosis. Walkup LL, Roach DJ, Hall CS, Gupta N, Thomen RP, Cleveland ZI, McCormack FX, Woods JC. Ann Am Thorac Soc. 2019 Apr 30. doi: 10.1513/AnnalsATS.201812-880OC.

• Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis. Wang JM, Robertson SH, Wang Z, He M, Virgincar RS, Schrank GM, Smigla RM, O'Riordan TG, Sundy J, Ebner L, Rackley CR, McAdams P, Driehuys B. Thorax. 2018 Jan;73(1):21-28. doi: 10.1136/thoraxjnl-2017-210070.

• Hyperpolarized Gas MR Imaging: Technique and Applications. Roos JE, McAdams HP, Kaushik SS, Driehuys B. Magn Reson Imaging Clin N Am. 2015 May;23(2):217-29. doi: 10.1016/j.mric.2015.01.003.

• Hyperpolarized 129Xe MRI of the human lung. Mugler JP 3rd, Altes TA. J Magn Reson Imaging. 2013 Feb;37(2):313-31. doi: 10.1002/jmri.23844

• Hyperpolarized (3) He and (129) Xe MRI: differences in asthma before bronchodilation. Svenningsen S, Kirby M, Starr D, Leary D, Wheatley A, Maksym GN, McCormack DG, Parraga G. J Magn Reson Imaging. 2013 Dec;38(6):1521-30. doi: 10.1002/jmri.24111.

• The role of hyperpolarized 129xenon in MR imaging of pulmonary function. Ebner L, Kammerman J, Driehuys B, Schiebler ML, Cadman RV, Fain SB. Eur J Radiol. 2017 Jan;86:343-352. doi: 10.1016/j.ejrad.2016.09.015.

• Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution. He M, Driehuys B, Que LG, Huang YT. Acad Radiol. 2016 Dec;23(12):1521-1531. doi: 10.1016/j.acra.2016.07.014.

• Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease. Santyr G, Kanhere N, Morgado F, Rayment JH, Ratjen F, Couch MJ.Acad Radiol. 2019 Mar;26(3):344-354. doi: 10.1016/j.acra.2018.04.024.

• Correlation of Lung Clearance Index with Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Subjects with Cystic Fibrosis. Kanhere N, Couch MJ, Kowalik K, Zanette B, Rayment JH, Manson D, Subbarao P, Ratjen F, Santyr G. Am J Respir Crit Care Med. 2017 Oct 15;196(8):1073-1075. doi: 10.1164/rccm.201611-2228LE

• Experimental validation of the hyperpolarized 129 Xe chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease. Stewart NJ, Leung G, Norquay G, Marshall H, Parra-Robles J, Murphy PS, Schulte RF, Elliot C, Condliffe R, Griffiths PD, Kiely DG, Whyte MK, Wolber J, Wild JM. Magn Reson Med. 2015 Jul;74(1):196-207.